邀请人：陈建刚 副研究员
开始时间：2021-5-13(周四) 下午14：30
讲座地点：闵行校区信息楼133会议室
主讲人简介：
吕毅，教授，西安交通大学校长助理，医学部副主任，西安交通大学第一附属医院院长、党委副书记，精准外科与再生医学国家地方联合工程研究中心主任，教育部创新团队学科带头人，卫生部有突出贡献中青年专家，陕西省“三秦学者”特聘教授，“西安市十佳创新人物”，美国外科医师协会会士（FACS），兼任中国电工技术学会生物电工专业委员会副主任委员、中国医学装备协会磁外科创新专家委员会主任委员、全国卫生产业企业管理协会医疗科技创新发展分会会长，陕西省高等学校学科创新引智基地（智能物理医学引智基地）主任，陕西省医工融合产业技术创新战略联盟理事长等。以第一完成人获国家科技进步二等奖、中华医学科技奖、教育部技术发明奖等20余项。主持科技部重点研发计划、国自然国家重大科学仪器研制、重点项目、仪器专项等近30项。在Annals of Surgery、Hepatology等发表SCI论文305篇。授权国家发明专利52项，申请美国专利1项。自主研发了肝移植术后随访、胆道造影、磁耦合吸痰、智能消毒、磁导航气管插管等医用机器人。
讲座摘要：
The biological effects and biomedical application of high voltage pulsed electric fields (PEF) has become the hot spot in recent years, which has been used for sterilization, gene electrotransfection, electrochemotherapy, electrodynamic therapy and tissue ablation. Irreversible electroporation (IRE), which is based on the biological effect of PEF, is an emerging non-thermal tumor ablation technique. It uses ultrashort high-voltage electric pulses to induce cell death through apoptosis or necrosis induced by either disrupting the balance of the transmembrane potential. This causes permanent membrane lysis, or secondary breakdown of the membrane due to abundant transmembrane transfer of electrolytes and adenosine triphosphate, leading to loss of cell homeostasis. Therefore, IRE has been treated as a focal ablative technique used for certain solid tumors that are unsuitable for surgery or thermal ablation because of their precarious anatomic location. In contrast to thermal ablation, IRE can achieve tumor ablation without affecting acellular tissue constituents, such as extracellular macromolecules, connective tissue and tissue scaffold, thereby avoiding irreversible thermal tissue damage. As a consequence, these characteristics theoretically make it attractive option for tumors in the vicinity of vital structures or those located in a cavity organ. Our team has gathered medical and engineering researchers, and has done a lot of work on the principle of PEF biological effect, the research and development of new ablation equipment and catheter-based electrodes. In this talk, I will present the research progress and future prospect for high voltage electroporation pulses and its clinical applications。
